DraftKings NFL DFS Week 15 Top Picks

Football on a field under stadium lights.
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It’s a new season every week when you play DFS. Time to take what we’ve learned, set our DraftKings lineups, and WIN some cash! Here are the DraftKings NFL DFS Week 15 Top Picks!

Looking for FanDuel NFL DFS Week 15 Top Picks? Click here.

Got DraftKings DFS questions? Reach out to me on Twitter @LLFantasySports, Facebook @LadiesLoveFantasySports, or Instagram @ladieslovefantasysports.

A white laptop computer with a red bullseye on the screen.

Games to Target this Week

  • Kansas City Chiefs @ New Orleans Saints – Implied Team Totals 51.5 points
  • Houston Texans @ Indianapolis Colts – Implied Team Totals 51 points
  • Philadelphia Eagles @ Arizona Cardinals – Implied Team Totals 48.5 points
  • Detroit Lions @ Tennessee Titans – Implied Team Totals 51.6 points
  • New York Jets @ Los Angeles Rams – Implied Team Totals 44 points (Rams favored by 17.5 points)
A football sitting on the grass with a stack of $20 bills on top

DraftKings Cash Game Lineups

Since you’re playing against smaller fields in cash games, and usually don’t have to place first to win money, the strategy for building cash lineups is to target players that produce consistent fantasy value.

Stay away from risky plays, and go with more proven situations. Here’s a list of recommended players for this weeks DraftKings Main Slate of Cash Games.

NFL Baltimore Ravens quarterback Lamar Jackson
All-Pro Reels/flickr/CC 2.0

Quarterbacks

  • Lamar Jackson BAL vs JAX $7500
  • Patrick Mahomes KC @ NO $7900
  • Jared Goff LAR vs NYJ $6300
  • Jalen Hurts PHI @ ARI $5900
Los Angeles Rams quarterback Jared Goff handing off the football to running back Cam Akers
All-Pro Reels/flickr/CC 2.0

Running Backs

  • Derrick Henry TEN vs DET $9500
  • Alvin Kamara NO vs KC $7400
  • Jonathan Taylor IND vs HOU $7200
  • David Montgomery CHI @ MIN $7000
  • Cam Akers LAR vs NYJ $6600
  • J.K. Dobbins BAL vs JAC $5900
  • Kenyan Drake ARI vs PHI $5500 (If Chase Edmonds is OUT)
  • Jeff Wilson Jr. SF @ DAL $5100
Kansas City Chiefs wide receiver Tyreek Hill outstretched diving for a touchdown against the Pittsburgh Steelers
Brook Ward/flickr/CC 2.0

Wide Receivers

  • Tyreek Hill KC @ NO $8800
  • Calvin Ridley ATL vs TB $8200
  • A.J. Brown TEN vs DET $7600
  • Allen Robinson II CHI @ MIN $7400
  • Brandon Aiyuk SF @ DAL $6300
  • T.Y. Hilton IND vs HOU $5500
  • Russell Gage ATL vs TB $4700
  • KeKe Coutee HOU @ IND $5300
NFL Baltimore Ravens tight end Mark Andrews
All-Pro Reels/flickr/CC 2.0

Tight Ends

  • Mark Andrews BAL vs JAX $5500
  • Travis Kelce KC @ NO $8000
  • Dallas Goedert PHI @ ARI $3900
  • Logan Thomas WAS vs SEA $4000
NFL Los Angeles Rams defensive tackle Aaron Donald
All-Pro Reels/flickr/CC 2.0

Defense

  • Los Angeles Rams vs NYJ $4500
  • Tampa Bay Buccaneers @ ATL $3000
  • San Francisco 49ers @ DAL $3100
  • Washington Football Team vs SEA $2600

A stack of hundred dollar bills in a silver briefcase

DraftKings GPP Tournament Lineups

In contrast to cash, your strategy changes when building GPP (Guaranteed Prize Pool) lineups where you have to beat out thousands of players to get a shot at winning big prizes. In these types of tournaments you’re targeting players that have high-upside for the week and low ownership so you can construct unique rosters.

These risky BOOM/BUST plays may not always hit, but when they do you have the potential to stack up that cash! Here’s a list of recommended players for this weeks DraftKings GPP Tournament Main Slate of games.

Los Angeles Rams quarterback Jared Goff throwing a pass against the Washington Football Team
All-Pro Reels/flickr/CC 2.0

Quarterbacks

  • Lamar Jackson BAL vs JAX $7500
  • Patrick Mahomes KC @ NO $7900
  • Kyler Murray ARI vs PHI $7000
  • Jared Goff LAR vs NYJ $6300
  • Tom Brady TB @ ATL $6600
  • Ryan Tannehill TEN vs DET $6700
  • Jalen Hurts PHI @ ARI $5900
  • Mitchell Trubisky CHI @ MIN $5500
NFL Baltimore Ravens running back J.K. Dobbins taking a handoff from quarterback RG3
All-Pro Reels/flickr/CC 2.0

Running Backs

  • Derrick Henry TEN vs DET $9500
  • Jonathan Taylor IND vs HOU $7200
  • Alvin Kamara NO vs KC $7400
  • Dalvin Cook MIN vs CHI $9000
  • J.K. Dobbins BAL vs JAC $5900
  • Miles Sanders PHI @ ARI $6900
  • Cam Akers LAR vs NYJ $6600
  • Kenyan Drake ARI vs PHI $5500 (If Chase Edmonds is OUT)
  • Jeff Wilson Jr. SF @ DAL $5100
  • Leonard Fournette TB @ ATL $4500
NFL Indianapolis Colts wide receiver T.Y. Hilton celebrating a touchdown against the Washington Football Team.
All-Pro Reels/flickr/CC 2.0

Wide Receivers

  • Tyreek Hill KC @ NO $8800
  • Calvin Ridley ATL vs TB $8200
  • A.J. Brown TEN vs DET $7600
  • Allen Robinson II CHI @ MIN $7400
  • Brandon Aiyuk SF @ DAL $6300
  • DeAndre Hopkins ARI vs PHI $7900
  • Robert Woods LAR vs NYJ $6800
  • Chris Godwin TB @ ATL $6200
  • T.Y. Hilton IND vs HOU $5500
  • Mike Evans TB @ ATL $6500
  • Justin Jefferson MIN vs CHI $7300
  • Terry McLaurin WAS vs SEA $6600
  • Russell Gage ATL vs TB $4700
  • KeKe Coutee HOU @ IND $5300
  • Michael Gallup DAL vs SF $3500
NFL Philadelphia Eagles tight end Dallas Goedert
All-Pro Reels/flickr/CC 2.0

Tight End

  • Mark Andrews BAL vs JAX $5500
  • Travis Kelce KC @ NO $8000
  • Dallas Goedert PHI @ ARI $3900
  • Rob Gronkowski TB @ ATL $4200
  • Logan Thomas WAS vs SEA $4000
  • Irv Smith Jr. MIN vs CHI $3600
  • Cole Kmet CHI @ MIN $3000
  • Hayden Hurst ATL vs TB $3300
NFL Tennessee Titans cornerback Tye Smith
Brook Ward/flickr/CC 2.0

Defense

  • Los Angeles Rams vs NYJ $4500
  • Tampa Bay Buccaneers @ ATL $3000
  • San Francisco 49ers @ DAL $3100
  • Washington Football Team vs SEA $2600
  • Tennessee Titans vs DET $3400
  • Seattle Seahawks @ WAS $3100
  • New England Patriots @ MIA $3000
  • Dallas Cowboys vs SF $2700
NFL Arizona Cardinals wide receiver DeAndre Hopkins celebrating a touchdown with quarterback Kyler Murray
All-Pro Reels/flickr/CC 2.0

Stacks

  • Lamar Jackson QB $7500/Mark Andrews TE $5500 JAX @ BAL
  • Patrick Mahomes QB $7900/Tyreek Hill WR $8800/Alvin Kamara RB $7400 KC @ NO
  • Tyreek Hill WR $8800/Travis Kelce TE $8000/Alvin Kamara RB $7400 KC @ NO
  • Tom Brady QB $6600/Chris Godwin WR $6200/Calvin Ridley WR $8200 TB @ ATL
  • Tom Brady QB $6600/Mike Evans WR $6500/Calvin Ridley WR $8200 TB @ ATL
  • Kyler Murray QB $7000/DeAndre Hopkins WR $7900 ARI vs PHI
  • Ryan Tannehill QB $6700/A.J. Brown WR $7600/Derrick Henry RB $9500 TEN vs DET
  • Alvin Kamara RB $7400/Travis Kelce TE $8000 KC @ NO
  • Jared Goff QB $6300/Robert Woods WR $6800/Cooper Kupp WR $7000 LAR vs NYJ
  • T.Y. Hilton WR $5500/Keke Coutee WR $5300 HOU @ IND

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