DraftKings NFL DFS Week 10 Top Picks

A football sitting on top of bags of money sitting on a football field.
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It’s a new season every week when you play DFS. Time to take what we’ve learned, set our DraftKings lineups, and WIN some cash! Here are my DraftKings NFL DFS Week 10 Top Picks!

Looking for FanDuel NFL DFS Week 10 Top Picks? Click here.

A white laptop computer with a red bullseye on the screen.

Games to Target this Week

  • Buffalo Bills @ Arizona Cardinals – Implied Team Totals 56 points
  • Seattle Seahawks @ Los Angeles Rams – Implied Team Totals 55.5 points
  • Jacksonville Jaguars @ Green Bay Packers – Implied Team Totals 50 points (Packers are favored by 13.5 points)
  • Tampa Bay Buccaneers @ Carolina Panthers – Implied Team Totals 50.5 points
  • Houston Texans @ Cleveland Browns – Implied Team Totals 49 points
A football sitting on the grass with a stack of $20 bills on top

DraftKings Cash Game Lineups

Since you’re playing against smaller fields in cash games, and usually don’t have to place first to win money, the strategy for building cash lineups is to target players that produce consistent fantasy value.

Stay away from risky plays, and go with more proven situations. Here’s a list of recommended players for this weeks DraftKings Main Slate of Cash Games.

NFL Arizona Cardinal quarterback Kyler Murray attempting a pass against the Washington Football Team
All-Pro Reels/flickr/CC 2.0

Quarterbacks

  • Kyler Murray ARI vs BUF $8000
  • Josh Allen BUF @ ARI $7500
  • Deshaun Watson HOU @ CLE $6900
  • Aaron Rodgers GB vs JAC $7900
  • Derek Carr LV vs DEN $5400
NFL Green Bay Packers running back Aaron Jones celebrating a big play in a game against the Washington Football Team.
KA Sports Photos/flickr/CC 2.0

Running Backs

  • Aaron Jones GB vs JAC $7100
  • Mike Davis CAR vs TB $4000
  • Alvin Kamara NO vs SF $8200
  • Duke Johnson HOU @ CLE $5000
  • Antonio Gibson WAS @ DET $5600
  • Josh Jacobs LV vs DEN $6500
NFL Los Angeles Chargers wide receiver Keenan Allen
Nathan Rupert/flickr/CC 2.0

Wide Receivers

  • Davante Adams GB vs JAC $9000
  • Keenan Allen LAC @ MIA $7100
  • Robert Woods LAR vs SEA $6600
  • Stefon Diggs BUF @ ARI $7500
  • Terry McLaurin WAS @ DET $6800
  • Brandin Cooks HOU @ CLE $5600
  • DJ Moore CAR vs TB $5100
  • Tim Patrick DEN @ LV $4900
  • Jakeem Grant MIA vs LAC $3000
NFL Las Vegas Raiders tight end Darren Waller catching a pass against the Indianapolis Colts defender
Jamie Lamor Thompson/shutterstock

Tight Ends

  • Darren Waller LV vs DEN $5900
  • Evan Engram NYG vs PHI $4500
  • T.J. Hockenson DET vs WAS $5100
  • Eric Ebron PIT vs CIN $4400
  • Dallas Goedert PHI @ NYG $4200
  • Logan Thomas WAS @ DET $3300
The NFL Philadelphia Eagles defense tackling Washington Football Team wide receiver Terry McLaurin
All-Pro Reels/flickr/CC 2.0

Defense

  • New Orleans Saints vs SF $3000
  • Las Vegas Raiders vs DEN $2500
  • Philadelphia Eagles @ NYG $3600
  • Green Bay Packers vs JAC $3700
  • Miami Dolphins vs LAC $2800
  • Los Angeles Rams vs SEA $2200

A stack of hundred dollar bills in a silver briefcase

DraftKings GPP Tournament Lineups

In contrast to cash, your strategy changes when building GPP (Guaranteed Prize Pool) lineups where you have to beat out thousands of players to get a shot at winning big prizes. In these types of tournaments you’re targeting players that have high-upside for the week and low ownership so you can construct unique rosters.

These risky BOOM/BUST plays may not always hit, but when they do you have the potential to stack up that cash! Here’s a list of recommended players for this weeks DraftKings GPP Tournament Main Slate of games.

NFL Los Angeles Rams quarterback Jared Goff running with the football in a game against the Washington Football Team
All-Pro Reels/flickr/CC 2.0

Quarterbacks

  • Kyler Murray ARI vs BUF $8000
  • Aaron Rodgers GB vs JAC $7900
  • Josh Allen BUF @ ARI $7500
  • Russell Wilson SEA @ LAR $7700
  • Deshaun Watson HOU @ CLE $6900
  • Justin Herbert LAC @ MIA $6600
  • Jared Goff LAR vs SEA $6500
  • Derek Carr LV vs DEN $5400
  • Drew Lock DEN @ LV $5500
  • Carson Wentz PHI @ NYG $5900
NFL Arizona Cardinals running back Chase Edmonds taking a handoff from quarterback Kyler Murray
All-Pro Reels/flickr/CC 2.0

Running Backs

  • Aaron Jones GB vs JAC $7100
  • Alvin Kamara NO vs SF $8200
  • James Robinson JAC @ GB $6600
  • Nick Chubb CLE vs HOU $6800
  • Mike Davis CAR vs TB $4000
  • Duke Johnson HOU @ CLE $5000 (If David Johnson is OUT)
  • Antonio Gibson WAS @ DET $5600
  • Chase Edmonds ARI vs BUF $6300
  • Darrell Henderson Jr. LAR $5900
  • Zack Moss BUF @ ARI $5200
  • Jamaal Williams GB vs JAC $4000
NFL Green Bay Packers wide receiver Devante Adams catching a pass against a Washington Football Team defender in a football game.
Keith Allison/flickr/CC 2.0

Wide Receivers

  • Michael Thomas NO vs SF $7400
  • Davante Adams GB vs JAC $9000
  • Robert Woods LAR vs SEA $6600
  • Will Fuller V HOU @ CLE $6700
  • Stefon Diggs BUF @ ARI $7500
  • DK Metcalf SEA @ LAR $7600
  • Cooper Kupp LAR vs SEA $6900
  • Tyler Lockett SEA @ LAR $6500
  • Terry McLaurin WAS @ DET $6800
  • Brandin Cooks HOU @ CLE $5600
  • Jerry Jeudy DEN @ LV $5600
  • Diontae Johnson PIT vs CIN $5200 (If Ben Roethlisberger PLAYS)
  • DJ Chark Jr. JAC @ GB $6200
  • Josh Reynolds LAR vs SEA $3500
  • John Brown BUF @ ARI $5300
  • Sterling Shepard NYG vs PHI $5000
  • Jalen Reagor PHI @ NYG $4200
  • Rashard Higgins CLE vs HOU $4600
NFL New York Giants tight end Evan Ingram catching a touchdown pass in the endzone
Arturo Holmes/shutterstock

Tight Ends

  • Darren Waller LV vs DEN $5900
  • T.J. Hockenson DET vs WAS $5100
  • Evan Engram NYG vs PHI $4500
  • Dallas Goedert PHI @ NYG $4200
  • Hunter Henry LAC @ MIA $4100
  • Noah Fant DEN @ LV $4900
  • Mike Gesicki MIA vs LAC $4300
  • Austin Hooper CLE vs HOU $3900
  • Jordan Reed SF @ NO $3500
NFL Green Bay Packers defense sacking Pittsburgh Steelers quarterback Ben Roethlisberger in a football game.
Brook Ward/flickr/CC 2.0

Defense

  • New Orleans Saints vs SF $3000
  • Las Vegas Raiders vs DEN $2500
  • Philadelphia Eagles @ NYG $3600
  • Green Bay Packers vs JAC $3700
  • Miami Dolphins vs LAC $2800
  • Los Angeles Rams vs SEA $2200
NFL Los Angeles Rams quarterback Jared Goff celebrating a touchdown against the Washington Footballwith fellow teammate Robert Woods
All-Pro Reels/flickr/CC 2.0

Stacks

  • Jared Goff QB $6500/Cooper Kupp WR $6900/Tyler Lockett WR $6500 SEA @ LAR
  • Jared Goff QB $6500/Robert Woods WR $6600/DK Metcalf WR $7600 SEA @ LAR
  • Russell Wilson QB $7700/Tyler Lockett WR $6500/Robert Woods WR $6600 SEA @ LAR
  • Aaron Rodgers QB $7900/Davante Adams WR $9000/DJ Chark Jr. WR $6200 JAC @ GB
  • Deshaun Watson QB $6900/Will Fuller WR $6700/Nick Chubb RB $6800 HOU @ CLE
  • Kyler Murray QB $8000/Chase Edmonds RB $6300/Stefon Diggs WR $7500 BUF @ ARI
  • Kyler Murray QB $8000/Christian Kirk WR $5700/Stefon Diggs WR $7500 BUF @ ARI
  • Kyler Murray QB $8000/DeAndre Hopkins WR $7700/John Brown WR $5300 BUF @ ARI
  • Drew Lock QB $5500/Jerry Jeudy WR $5600/Darren Waller TE $5900 DEN @ LV
  • Michael Thomas WR $7400/Alvin Kamara RB $8200/Brandon Aiyuk WR $5700 SF @ NO
  • Michael Thomas WR $7400/Alvin Kamara $8200/Jordan Reed TE $3500 SF @ NO
  • Carson Wentz QB $5900/ WR $/Travis Fulgham WR $6400/Dallas Goedert TE $4200/Sterling Shepard WR $5000 PHI @ NYG
  • Carson Wentz QB $5900/Jalen Reagor WR $4200/Dallas Goedert TE $4200/Sterling Shepard WR $5000 PHI @ NYG

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